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My youngest son has suffered with Schizophrenia for some 6 years now. It is horrible when someone in your family suffers from this disease. You can never feel absolutely confident and happy any more. We have tried our boy on many medications - some of them were ok, some left much to be desired but actually none produced the desired effect, the relief we were dreaming about. And still another problem with such meds is that after a while they lose their effectiveness. But Clozapine is completely different. After being on it for more than two years my son is still stable, with no side effects and nothing changed in the effect the medication produces on his condition. We hope it will continue working as Clozapine is the best thing we have tried.


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My older brother has had schizoprenia since he was 14 years old in 1970's. He has been on many, many medicines with some or little success. He was then put on Clozaril in his thirty's, what a miracle Clozaril was. He was able to live a almost normal life for over 10 years and within 3 days his life went from happy to hell again, because of his blood test result, we tried to get him back on it but due to the special list with people who have reactions to it are not able to ever take it again. My brother is one of the lucky one's though he has a family that totally supports him and encourages him to live and do the best that he can. He lives in a adult facility that takes care of his needs and makes sure he gets his medicines.

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An individual with prior relationships devastated by the disability may become avoidant or despondent about the possibility of “trying again”.

Clozapine tablets can cause neutropenia (a low absolute neutrophil count (ANC)), defined as a reduction below pre-treatment normal levels of blood neutrophils.

Patients should be advised not to engage in any activity where sudden loss of consciousness could cause serious risk to themselves or others.

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In patients with a history of severe or recent mania, lamotrigine should be used in combination with lithium, olanzapine, or aripiprazole.

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Ensure that the patient has stopped taking any antidepressant or mania inducing substances.

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Although available data are too sparse to draw reliable conclusions, the small amount of human data plus animal data suggest that ziprasidone should be less preferred than other atypical antipsychotics during pregnancy.

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Because anyone can be a carrier of these diseases and symptoms do not have to occur for a person to be contagious, universal precautions greatly reduce the chances of exposure because they require that all human blood and certain human body fluids are treated as if known to be infectious for HIV, HBV, and other bloodborne pathogens.

While clozapine is beneficial for some patients, there are risks associated with this drug.

For example, patients taking clozapine would never require benztropine, as clozapine has inherent anticholinergic properties.

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National Association of State Mental Health Program Directors (NASMHPD) and National Association of State Alcohol and Drug Abuse Directors (NASADAD) Financing and marketing the new conceptual framework for co-occurring mental health and substance use disorders: A blueprint for systems change.

For the most up-to-date information on the management of clozapine tablets overdosage, contact a certified Regional Poison Control Center (1-800-222-1222).

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