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Several of the 48 cases indicated the patients were intentionally misusing concomitant drugs that are cytochrome P450 (CYP3A4 or CYP2C8) or P-glycoprotein inhibitors, such as quinidine, which have the potential for drug-drug interactions with loperamide that can increase the blood levels and the effects of loperamide.
Other dopamine agonists that have tested in small studies include alpha-dihydroergocryptine, or DHEC (Almirid), and piribedil (Trivastal).
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